Cytotoxic Homo- and Hetero-Dimers of o-toluidine, o-anisidine, and Aniline Formed by In Vitro Metabolism

Author:

Kobayashi Takuma1,Kishimoto Shinji2,Watanabe Shogo2,Yoshioka Yasukiyo1,Toyoda Takeshi3,Ogawa Kumiko3,Watanabe Kenji2ORCID,Totsuka Yukari45ORCID,Wakabayashi Keiji1,Miyoshi Noriyuki1ORCID

Affiliation:

1. Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 422-8526, Japan

2. Department of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan

3. Division of Pathology, National Institute of Health Sciences, Kanagawa 210-9501, Japan

4. Laboratory of Environmental Toxicology and Carcinogenesis, Nihon University School of Pharmacy, Chiba 274-8555, Japan

5. Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo 104-0045, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Ministry of Health, Labour and Welfare

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference18 articles.

1. IARC Monographs Working Group on the Evaluation of Carcinogenic Risks to Humans. Some Aromatic Amines, Organic Dyes, and Related Exposures. IARC monographs on the evaluation of carcinogenic risks to humans, 2010; Vol. 99, pp 1–658.

2. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Chemical Agents and Related Occupations. ARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 2012; Vol. 100(Pt F), pp 9–562.

3. Program, N.T. Report on Carcinogens Monograph on Ortho-Toluidine, 2016; Vol. 1–129.

4. National Toxicology Program. O-Anisidine and Its Hydrochloride. Report on Carcinogens 2011; Vol. 12, pp 43–45.

5. IARC Monographs Vol 127 group. Carcinogenicity of Some Aromatic Amines and Related Compounds. Lancet. Oncology 2020; Vol. 21(8), pp 1017–1018.

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