A Scalable Oxidation for the Final Stage of Synthesis of Cathepsin K Inhibitor SB-462795
Author:
Affiliation:
1. GlaxoSmithKline, Synthetic Chemistry, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op100266s
Reference29 articles.
1. Large-scale synthesis of SB-462795, a cathepsin K inhibitor: the RCM-based approaches
2. A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys
3. Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors
4. cCummings, M. D.; Marquis, R. W.; Ru, Y.; Thompson, S. K.; Veber, D. F.; Yamashita, D. S.PCT Int. Appl. WO/2001/070232 A1, 2001.
5. Large-Scale Oxidations in the Pharmaceutical Industry
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