Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors-Reference-Cited by-同舟云学术

Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors

Published:2006-02-15 Issue:5 Volume:49 Page:1597-1612
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yamashita Dennis S.¹,Marquis Robert W.¹,Xie Ren¹,Nidamarthy Sirishkumar D.¹,Oh Hye-Ja¹,Jeong Jae U.¹,Erhard Karl F.¹,Ward Keith W.¹,Roethke Theresa J.¹,Smith Brian R.¹,Cheng H-Y.¹,Geng Xiaoliu¹,Lin Fan¹,Offen Priscilla H.¹,Wang Bing¹,Nevins Neysa¹,Head Martha S.¹,Haltiwanger R. Curtis¹,Narducci Sarjeant Amy A.¹,Liable-Sands Louise M.¹,Zhao Baoguang¹,Smith Ward W.¹,Janson Cheryl A.¹,Gao Enoch¹,Tomaszek Thaddeus¹,McQueney Michael¹,James Ian E.¹,Gress Catherine J.¹,Zembryki Denise L.¹,Lark Michael W.¹,Veber Daniel F.¹

Affiliation:

1. Departments of Medicinal Chemistry; Drug Metabolism and Pharmacokinetics; Musculoskeletal Diseases Biology; Computational, Analytical, and Structural Sciences; and Screening and Compound Profiling, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050915u

Reference20 articles.

1. Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

2. Structure and Design of Potent and Selective Cathepsin K Inhibitors

3. The Henry reaction: recent examples

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