Structure and Design of Potent and Selective Cathepsin K Inhibitors-Reference-Cited by-同舟云学术

Structure and Design of Potent and Selective Cathepsin K Inhibitors

Published:1997-11-01 Issue:46 Volume:119 Page:11351-11352
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Yamashita Dennis S.¹,Smith Ward W.¹,Zhao Baoguang¹,Janson Cheryl A.¹,Tomaszek Thaddeus A.¹,Bossard Mary J.¹,Levy Mark A.¹,Oh Hye-Ja¹,Carr Thomas J.¹,Thompson Scott K.¹,Ijames Carl F.¹,Carr Steven A.¹,McQueney Michael¹,D'Alessio Karla J.¹,Amegadzie Bernard Y.¹,Hanning Charles R.¹,Abdel-Meguid Sherin¹,DesJarlais Renee L.¹,Gleason John G.¹,Veber Daniel F.¹

Affiliation:

1. Departments of Medicinal Chemistry, Macromolecular Sciences, Molecular Recognition, Structural and Physical Chemistry, Protein Biochemistry, and Gene Expression Sciences SmithKline Beecham Pharmaceuticals, 709 Swedeland Rd. King of Prussia, Pennsylvania 19406

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja972204u

Reference17 articles.

1. Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts

2. Proteolytic Activity of Human Osteoclast Cathepsin K

3. Crystal structure of human cathepsin K complexed with a potent inhibitor

4. Crystal structure of human osteoclast cathepsin K complex with E-64

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