Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe-Reference-Cited by-同舟云学术

Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe

Published:2022-01-25 Issue:2 Volume:17 Page:340-347
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Jung Yejin¹²,Noda Naotaka¹²,Takaya Junichiro¹²,Abo Masahiro¹,Toh Kohei¹,Tajiri Ken¹,Cui Changyi³,Zhou Lu³^ORCID,Sato Shin-ichi¹^ORCID,Uesugi Motonari¹³⁴^ORCID

Affiliation:

1. Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan

2. Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

3. School of Pharmacy, Fudan University, Shanghai 201203, China

4. Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Uji, Kyoto 611-0011, Japan

Funder

Japan Society for the Promotion of Science

Kyoto University

Kobayashi International Scholarship Foundation

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.1c00824

Reference52 articles.

1. Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies

2. The resurgence of covalent drugs

3. Privileged Electrophile Sensors: A Resource for Covalent Drug Development

4. Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation

5. Irreversible Protein Kinase Inhibitors: Balancing the Benefits and Risks

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