Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
Author:
Publisher
Elsevier BV
Subject
Drug Discovery,Pharmacology
Reference90 articles.
1. Deriving KI and Kinact directly from time-dependent IC50 values;Krippendorff;J. Biomol. Screen.,2009
2. Targeted covalent enzyme inhibitors;Noe;Annu. Rep. Med. Chem.,2012
3. Mechanistic basis of enzyme-targeted drugs;Robertson;Biochemistry,2005
4. The resurgence of covalent drugs;Singh;Nat. Rev. Drug Discov.,2011
5. Covalent modifiers: an orthogonal approach to drug design;Potashman;J. Med. Chem.,2009
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