Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation

Author:

Badr Christian E.1ORCID,da Hora Cintia Carla1,Kirov Aleksandar B.1,Tabet Elie1,Amante Romain1,Maksoud Semer1,Nibbs Antoinette E.2,Fitzsimons Evelyn1,Boukhali Myriam3,Chen John W.24,Chiu Norman H. L.5,Nakano Ichiro6,Haas Wilhelm3,Mazitschek Ralph27,Tannous Bakhos A.1

Affiliation:

1. Experimental Therapeutics and Molecular Imaging Unit, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States

2. Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States

3. Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, United States

4. Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States

5. Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Caroline 27402, United States

6. Department of Neurosurgery and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States

7. Broad Institute of Harvard & Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, United States

Funder

National Cancer Institute

National Institute of Neurological Disorders and Stroke

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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