Thermodynamic profiling of inhibitors of Nrf2:Keap1 interactions
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference22 articles.
1. Toward clinical application of the Keap1–Nrf2 pathway
2. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
3. Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism
4. Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
5. Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction
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1. Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor;ACS Medicinal Chemistry Letters;2023-04-07
2. Dual role of Nrf2 in cancer: molecular mechanisms, cellular functions and therapeutic interventions;Molecular Biology Reports;2022-12-13
3. Insight into Thermodynamic and Kinetic Profiles in Small-Molecule Optimization;Journal of Medicinal Chemistry;2022-08-15
4. DJ-1 modulates Nrf2-mediated MRP1 expression by activating Wnt3a/β-catenin signalling in A549 cells exposed to cigarette smoke extract and LPS;Life Sciences;2021-07
5. Design, Synthesis, and Structure–Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein–Protein Interaction Inhibitors;Journal of Medicinal Chemistry;2020-09-09
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