Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases-Reference-Cited by-同舟云学术

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Published:2019-01-04 Issue:4 Volume:18 Page:295-317
ISSN:1474-1776
Container-title:Nature Reviews Drug Discovery
language:en
Short-container-title:Nat Rev Drug Discov

Author:

Cuadrado Antonio,Rojo Ana I.,Wells Geoffrey^ORCID,Hayes John D.,Cousin Sharon P.,Rumsey William L.,Attucks Otis C.,Franklin Stephen,Levonen Anna-Liisa,Kensler Thomas W.,Dinkova-Kostova Albena T.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Link

http://www.nature.com/articles/s41573-018-0008-x.pdf

Reference328 articles.

1. Moi, P., Chan, K., Asunis, I., Cao, A. & Kan, Y. W. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc. Natl Acad. Sci. USA 91, 9926–9930 (1994). This article describes the identification of NRF2 as a member of the human CNC basic-region leucine zipper transcription factor family.

2. Itoh, K. et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 236, 313–322 (1997). This paper describes the identification of NRF2 as the transcription factor that mediates the expression of cytoprotective genes through AREs.

3. Chan, K., Lu, R., Chang, J. C. & Kan, Y. W. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc. Natl Acad. Sci. USA 93, 13943–13948 (1996).

4. Hayes, J. D. & Dinkova-Kostova, A. T. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem. Sci. 39, 199–218 (2014).

5. Itoh, K. et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13, 76–86 (1999). This article describes the identification of KEAP1 as the main negative regulator of NRF2.

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