Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives
Author:
Affiliation:
1. Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge, United Kingdom CB4 0QA
2. CRUK Cancer Therapeutics Unit, Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey, United Kingdom SM2 5NG
Funder
Cancer Research UK
Royal Marsden NHS Foundation Trust
Publisher
American Chemical Society (ACS)
Subject
Molecular Medicine,General Medicine,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acschembio.6b00308
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1. Cancer Epigenetics: From Mechanism to Therapy
2. Molecular Pathways: Protein Methyltransferases in Cancer
3. Many Multiple Myelomas: Making More of the Molecular Mayhem
4. The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid Transcripts
5. In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression
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