A Mechanistic Insight into a Simple C−N Bond Formation via SN2 Displacement: A Synergistic Kinetics and Design of Experiment Approach

Author:

Massari Luca1,Panelli Laura1,Hughes Mark1,Stazi Federica1,Maton William1,Westerduin Pieter1,Scaravelli Federico1,Bacchi Sergio1

Affiliation:

1. Chemical Development, Synthetic Chemistry, GlaxoSmithKline Medicine Research Centre, Via Fleming 4, 37135 Verona, Italy, Chemical Development, Particle and Process Science and Engineering, GlaxoSmithKline Medicine Research Centre, Via Fleming 4, 37135 Verona, Italy, and Continuous Processing, Particle and Process Science and Engineering, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference25 articles.

1. 1,2,4-Triazolyl Azabicyclo[3.1.0]hexanes: A New Series of Potent and Selective Dopamine D3 Receptor Antagonists

2. aArista, L.; Bonanomi, G.; Capelli, A. M.; Damiani, F.; Di-Fabio, R.; Gentile, G.; Hamprecht, D.; Micheli, F.; Tarsi, L.; Tedesco, G.; Terreni, S.PCT Int. Appl. WO/2005/080382, 2005.

3. bBonanomi, G.; Checchia, A.; Fazzolari, E.; Hamprecht, D.; Micheli, F.; Tarsi, L.; Terreni, S.PCT Int. Appl. WO/2006/108701, 2006.

4. cArista, L.; Cardullo, F.; Cecchia, A.; Hamprecht, D.; Micheli, F.; Tedesco, G.; Terreni, S.PCT Int. Appl. WO/2006/133946, 2006.

5. The ICH Guidance Q8 represents the U.S. Food and Drug Administration (FDA) current thinking on Pharmaceutical Development manufacturing process. This guidance describes the suggested contents to input in a regulatory submission providing an opportunity to present the knowledge gained through the application of scientific approaches and quality risk management to the development of a product and its manufacturing process. This guidance is part of a set of Guidance for Industry developed within the Expert Working Group (Quality) of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).

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