Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6-Reference-Cited by-同舟云学术

Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6

Published:2022-09-08 Issue:18 Volume:61 Page:1945-1954
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Watson Paris R.¹,Bai Ping²^ORCID,Wang Changning²^ORCID,Cragin Abigail D.¹^ORCID,Hooker Jacob M.²^ORCID,Christianson David W.¹^ORCID

Affiliation:

1. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States

2. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, United States

Funder

Biological and Environmental Research

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.2c00332

Reference39 articles.

1. Metabolic and Pharmaceutical Aspects of Fluorinated Compounds

2. The Many Roles for Fluorine in Medicinal Chemistry

3. Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

4. Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

5. Fluorine in Pharmaceuticals: Looking Beyond Intuition

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases;Accounts of Chemical Research;2024-03-26

2. Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice;Journal of Medicinal Chemistry;2023-11-16

3. Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors;European Journal of Medicinal Chemistry;2023-06