Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice

Author:

Bai Ping12345,Liu Yan6,Yang Liuyue7,Ding Weihua7ORCID,Mondal Prasenjit8ORCID,Sang Na12345,Liu Gang9,Lu Xiaoxia9,Ho Thanh Tu10ORCID,Zhou Yanting12345,Wu Rui12345,Birar Vishal C.6,Wilks Moses Q.11,Tanzi Rudolph E.8,Lin Hening1012ORCID,Zhang Can8ORCID,Li Weimin12345ORCID,Shen Shiqian7,Wang Changning6ORCID

Affiliation:

1. Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

2. Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

3. Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

4. The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan 610041, China

5. State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan 610041, China

6. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States

7. Department of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States

8. Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, United States

9. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China

10. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States

11. Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States

12. Howard Hughes Medical Institute; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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