Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity-Reference-Cited by-同舟云学术

Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity

Published:2021-12-15 Issue:51 Volume:60 Page:3856-3867
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Singh Jai Prakash¹²³,Lin Meng-Jung¹,Hsu Shu-Fang¹,Peti Wolfgang⁴^ORCID,Lee Cheng-Chung¹^ORCID,Meng Tzu-Ching¹²⁵^ORCID

Affiliation:

1. Institute of Biological Chemistry, Academia Sinica, 128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan

2. Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Academia Sinica, 128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan

3. Department of Chemistry, National Tsing Hua University, 101, Kuang-Fu Road, Sec. 2, Hsinchu 300, Taiwan

4. Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, Connecticut 06030, United States

5. Institute of Biochemical Sciences, National Taiwan University, 1 Roosevelt Road Sec. 4, Taipei 106, Taiwan

Funder

Academia Sinica

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.1c00519

Reference44 articles.

1. Protein tyrosine phosphatases: regulatory mechanisms

2. Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction

3. Protein tyrosine phosphatases: from genes, to function, to disease

4. Allosteric inhibition of protein tyrosine phosphatase 1B

5. Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery

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