Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases-Reference-Cited by-同舟云学术

Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases

Published:2024-05-20 Issue:11 Volume:67 Page:8817-8835
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dong Jiajun¹,Jassim Brenson A.¹,Milholland Kedric L.²,Qu Zihan³,Bai Yunpeng¹,Miao Yiming¹,Miao Jinmin¹,Ma Yuan¹,Lin Jianping¹,Hall Mark C.²⁴⁵⁶^ORCID,Zhang Zhong-Yin¹³⁴⁵⁶^ORCID

Affiliation:

1. Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States

2. Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, United States

3. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States

4. Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States

5. Institute for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States

6. Institute for Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, Indiana 47907, United States

Funder

National Cancer Institute

National Institute of Allergy and Infectious Diseases

Purdue University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00149

Reference92 articles.

1. Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases

2. PTP1B and TC-PTP: regulators of transformation and tumorigenesis

3. Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

4. Coordinated Regulation of Insulin Signaling by the Protein Tyrosine Phosphatases PTP1B and TCPTP

5. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

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