Structural Evidence for Rifampicin Monooxygenase Inactivating Rifampicin by Cleaving Its Ansa-Bridge
Author:
Affiliation:
1. Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, United States
Funder
Division of Chemistry
Division of Molecular and Cellular Biosciences
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.8b00190
Reference13 articles.
1. Rifampin Combination Therapy for Nonmycobacterial Infections
2. Role of rifampin for the treatment of bacterial infections other than mycobacteriosis
3. Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance
4. Mechanism of Rifampicin Inactivation in Nocardia farcinica
5. Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action
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