Synthesis and Target Identification of a Novel Electrophilic Warhead, 2-Chloromethylquinoline-Reference-Cited by-同舟云学术

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Synthesis and Target Identification of a Novel Electrophilic Warhead, 2-Chloromethylquinoline

Published:2019-06-04 Issue:24 Volume:58 Page:2715-2719
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Ni Feng¹²,Ekanayake Arunika¹²,Espinosa Bianca¹²,Yu Caiqun¹²,Sanders Jacob N.³,Perino John¹²,Houk K. N.³^ORCID,Zhang Chao¹²^ORCID

Affiliation:

1. Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States

2. Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California 90089, United States

3. Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States

Funder

Division of Chemistry

University of Southern California

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.9b00359

Reference23 articles.

1. Covalent Modifiers: An Orthogonal Approach to Drug Design

2. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

3. Covalent targeting of acquired cysteines in cancer

4. Determining Cysteines Available for Covalent Inhibition Across the Human Kinome

5. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

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1. Discovery of Artemisinins as Microsomal Prostaglandins Synthase-2 Inhibitors for the Treatment of Colorectal Cancer via Chemoproteomics;Journal of Medicinal Chemistry;2024-01-29

2. The expanding repertoire of covalent warheads for drug discovery;Drug Discovery Today;2023-12

3. Pairs of thiol-substituted 1,2,4-triazole-based isomeric covalent inhibitors with tunable reactivity and selectivity;Chinese Chemical Letters;2023-09

4. Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease;International Journal of Molecular Sciences;2023-02-03

5. Identification of Covalent Ligands – from Single Targets to Whole Proteome;Israel Journal of Chemistry;2023-01-16

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