Discovery of Artemisinins as Microsomal Prostaglandins Synthase-2 Inhibitors for the Treatment of Colorectal Cancer via Chemoproteomics

Author:

Geng Yiyun12ORCID,Li Weichao3ORCID,Wong Nai-Kei4,Xue Fuchong1,Li Qing12,Zhang Yang5,Xu Jingyuan1,Deng Zhangshuang2,Zhou Yiqing12ORCID

Affiliation:

1. School of Biotechnology and Food Engineering, Changshu Institute of Technology, Suzhou 215500, China

2. Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China

3. CAS Key Laboratory of Synthetic Biology, Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China

4. Clinical Pharmacology Section, Department of Pharmacology, Shantou University Medical College, Shantou 515041, China

5. CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

Funder

Natural Science Research of Jiangsu Higher Education Institutions of China

Qinglan Project of Jiangsu Province of China

Natural Science Foundation of Jiangsu Province

Li Ka Shing Foundation

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

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