Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers-Reference-Cited by-同舟云学术

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Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers

Published:2021-05-14 Issue:21 Volume:60 Page:1682-1698
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Morris Elizabeth R.¹,Kunzelmann Simone²,Caswell Sarah J.¹,Purkiss Andrew G.²,Kelly Geoff³,Taylor Ian A.¹^ORCID

Affiliation:

1. Macromolecular Structure Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.

2. Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.

3. The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.

Funder

Medical Research Council

Wellcome Trust

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.0c00944

Reference78 articles.

1. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

2. Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

3. Identification of human homologue of mouse IFN-γ induced protein from human dendritic cells

4. SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+T-cells

5. The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis;Nature Communications;2024-05-06

2. Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel;iScience;2024-02

3. Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding;ACS Chemical Biology;2023-05-26

4. Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells;Retrovirology;2023-05-01

5. Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1viaa comprehensive screening funnel;2023-01-18

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