Site-Specific Conjugation Strategy for Dual Antibody–Drug Conjugates Using Aerobic Formylglycine-Generating Enzymes

Author:

Boschanski Mareile1,Krüger Tobias2,Karsten Lennard3,Falck Georg3,Alam Sarfaraz1,Gerlach Marcus2,Müller Benjamin4,Müller Kristian M.3ORCID,Sewald Norbert2ORCID,Dierks Thomas1

Affiliation:

1. Biochemistry, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany

2. Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany

3. Cellular and Molecular Biotechnology, Faculty of Technology, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany

4. Biofidus AG, Morgenbreede 1, 33615 Bielefeld, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Reference44 articles.

1. Antibody–Drug Conjugates for Cancer Treatment

2. Woodcock, J. (2020) Through Innovation New Drug Therapy Approvals 2019, pp 144, US Food and Drug Administration. https://www.fda.gov/media/134493/download (last accessed on May 14, 2021).

3. Hydrophilic Sequence-Defined Cross-Linkers for Antibody–Drug Conjugates

4. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

5. An α-Formylglycine Building Block for Fmoc-Based Solid-Phase Peptide Synthesis

Cited by 17 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3