Site-Specific Conjugation Strategy for Dual Antibody–Drug Conjugates Using Aerobic Formylglycine-Generating Enzymes-Reference-Cited by-同舟云学术

Site-Specific Conjugation Strategy for Dual Antibody–Drug Conjugates Using Aerobic Formylglycine-Generating Enzymes

Published:2021-06-01 Issue:6 Volume:32 Page:1167-1174
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Boschanski Mareile¹,Krüger Tobias²,Karsten Lennard³,Falck Georg³,Alam Sarfaraz¹,Gerlach Marcus²,Müller Benjamin⁴,Müller Kristian M.³^ORCID,Sewald Norbert²^ORCID,Dierks Thomas¹

Affiliation:

1. Biochemistry, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany

2. Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany

3. Cellular and Molecular Biotechnology, Faculty of Technology, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany

4. Biofidus AG, Morgenbreede 1, 33615 Bielefeld, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.1c00246

Reference44 articles.

1. Antibody–Drug Conjugates for Cancer Treatment

2. Woodcock, J. (2020) Through Innovation New Drug Therapy Approvals 2019, pp 144, US Food and Drug Administration. https://www.fda.gov/media/134493/download (last accessed on May 14, 2021).

3. Hydrophilic Sequence-Defined Cross-Linkers for Antibody–Drug Conjugates

4. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

5. An α-Formylglycine Building Block for Fmoc-Based Solid-Phase Peptide Synthesis

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