Cathepsin B Cleavage of vcMMAE-Based Antibody–Drug Conjugate Is Not Drug Location or Monoclonal Antibody Carrier Specific-Reference-Cited by-同舟云学术

Cathepsin B Cleavage of vcMMAE-Based Antibody–Drug Conjugate Is Not Drug Location or Monoclonal Antibody Carrier Specific

Published:2016-03-10 Issue:4 Volume:27 Page:1040-1049
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Gikanga Benson¹,Adeniji Nia S.¹,Patapoff Thomas W.¹,Chih Hung-Wei¹,Yi Li¹

Affiliation:

1. Pharmaceutical Processing and Technology Development, ‡Late Stage Pharmaceutical Development, §Early Stage Pharmaceutical Development, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.6b00055

Reference42 articles.

1. Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

2. Technology Insight: cytotoxic drug immunoconjugates for cancer therapy

3. Antibody-Drug Conjugates for Cancer Therapy

4. Antibody–drug conjugates – a perfect synergy

5. Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

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