Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species-Reference-Cited by-同舟云学术

Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species

Published:2024-04-22 Issue: Volume: Page:1-13
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Yip Victor¹,Saad Ola M.²,Leipold Doug¹,Li Chunze³,Kamath Amrita¹,Shen Ben-Quan¹

Affiliation:

1. Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080

2. BioAnalytical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080

3. Clinical Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2024.2345849

Reference21 articles.

1. Akaiwa M Dugal-Tessier J Mendelsohn BA. (2020) Antibody-Drug Conjugate Payloads; Study of Auristatin Derivatives. Chem Pharm Bull (Tokyo) 68:201-211.

2. Caculitan NG Dela Cruz Chuh J Ma Y Zhang D Kozak KR Liu Y Pillow TH Sadowsky J Cheung TK Phung Q et al. (2017) Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates. Cancer Res 77:7027-7037.

3. Chang HP Cheung YK Shah DK. (2021) Whole-Body Pharmacokinetics and Physiologically Based Pharmacokinetic Model for Monomethyl Auristatin E (MMAE). J Clin Med 10(6):1332.

4. Davies B Morris T. (1993) Physiological parameters in laboratory animals and humans. Pharm Res. 10(7):1093-5.

5. Donaghy H. (2016) Effects of antibody drug and linker on the preclinical and clinical toxicities of antibody-drug conjugates. MAbs 8:659-71.

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Preface for Special Issue: “Emerging strategies, technologies and approaches for the next generation ADCs”;Xenobiotica;2024-07-29

2. Antibody–drug conjugates in cancer therapy: mechanisms and clinical studies;MedComm;2024-07-28