Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity

Published:2013-10-22 Issue:21 Volume:56 Page:8696-8711
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

de Candia Modesto¹,Fiorella Filomena¹,Lopopolo Gianfranco¹,Carotti Andrea²,Romano Maria Rosaria¹,Lograno Marcello Diego¹,Martel Sophie³,Carrupt Pierre-Alain³,Belviso Benny D.⁴,Caliandro Rocco⁴,Altomare Cosimo¹

Affiliation:

1. Dipartimento di Farmacia-Scienze del Farmaco, University of Bari “Aldo Moro”, Via E. Orabona 4, 70125 Bari, Italy

2. Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, Via del Liceo 1, 60123 Perugia, Italy

3. School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland

4. Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Via Amendola 122/o, 70126 Bari, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401169a

Reference66 articles.

1. Triggers, targets and treatments for thrombosis

2. Venous Thromboembolism

3. Prevention of Venous Thromboembolism in Patients with Hemorrhagic Stroke

4. Pharmacological Strategies for Inhibition of Thrombin Activity

5. New oral Xa and IIa inhibitors: updates on clinical trial results

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