In-Depth Structure and Function Characterization of Heterogeneous Interchain Cysteine-Conjugated Antibody

In-Depth Structure and Function Characterization of Heterogeneous Interchain Cysteine-Conjugated Antibody–Drug Conjugates

Published:2023-12-12 Issue:1 Volume:7 Page:212-221
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Chen Huijie¹^ORCID,Qiu Danye²,Shi Jian¹,Wang Ningning³,Li Muchen³,Wu Ying¹,Tian Yu⁴,Bu Xiaodong⁵^ORCID,Liu Qingyuan⁶,Jiang Yanrui⁷,Hamilton Simon E.⁸,Han Ping⁶,Sun Shuwen⁵^ORCID

Affiliation:

1. Analytical Sciences, WuXi Biologics, 31 Yiwei Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

2. Analytical Sciences, WuXi Biologics, 1150 Lanfeng Road, Fengxian District, Shanghai 201403, China

3. WuXi Process Development Analytical Science, WuXi Biologics, 200 Meiliang Road, Binhu District, WuXi, Jiangsu 214092, China

4. Biologics Innovation & Discovery, WuXi Biologics, 227 Meisheng Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

5. Analytical Research & Development, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States

6. Analytical Research & Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

7. Analytical Research & Development, MSD, Industrie Nord 1, Schachen (Luzern) CH-6105, Switzerland

8. Analytical Research & Development, MSD, 120 Moorgate, London EC2M 6UR, U.K.

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.3c00235

Reference37 articles.

1. Antibody drug conjugate: the “biological missile” for targeted cancer therapy

2. Site-specific antibody-drug conjugate heterogeneity characterization and heterogeneity root cause analysis

3. Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs

4. Current ADC Linker Chemistry

5. Cysteine-Based Coupling: Challenges and Solutions

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