“Build Your Own” ADC Mimics: Identification of Nontoxic Linker/Payload Mimics for HIC-Based DAR Determination, High-Throughput Optimization, and Continuous Flow Conjugation-Reference-Cited by-同舟云学术

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“Build Your Own” ADC Mimics: Identification of Nontoxic Linker/Payload Mimics for HIC-Based DAR Determination, High-Throughput Optimization, and Continuous Flow Conjugation

Published:2024-07-17 Issue:8 Volume:28 Page:3326-3338
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Emmert Marion H.¹^ORCID,Bottecchia Cecilia¹^ORCID,Barrientos Rodell C.²^ORCID,Feng Yinnian¹,Holland-Moritz Daniel¹^ORCID,Hughes Gregory J.¹,Lam Yu-Hong³^ORCID,Regalado Erik L.²^ORCID,Ruccolo Serge¹,Sun Shuwen²^ORCID,Chmielowski Rebecca¹,Yang Cuixian¹,Lévesque François¹^ORCID,Raymond Kelly²,Haley Monica²

Affiliation:

1. Process Research & Development (PRD), MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Analytical Research & Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States

3. Modeling & Informatics, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00226

Reference53 articles.

1. A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads

2. Antibody–Drug Conjugates: A Review of Approved Drugs and Their Clinical Level of Evidence

3. The Legumain Protease-Activated Auristatin Prodrugs Suppress Tumor Growth and Metastasis without Toxicity

4. Considerations for the Nonclinical Safety Evaluation of Antibody–Drug Conjugates

5. Clinical toxicity of antibody drug conjugates: a meta-analysis of payloads

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