General Stepwise Approach to Optimize a TR-FRET Assay for Characterizing the BRD/PROTAC/CRBN Ternary Complex
Author:
Affiliation:
1. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States
Funder
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Pharmacology (medical),Pharmacology
Link
https://pubs.acs.org/doi/pdf/10.1021/acsptsci.1c00032
Reference25 articles.
1. Targeted protein degradation: elements of PROTAC design
2. The PROTAC technology in drug development
3. Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs
4. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
5. Assays and technologies for developing proteolysis targeting chimera degraders
Cited by 12 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Using Förster Resonance Energy Transfer (FRET) to Understand the Ubiquitination Landscape;ChemBioChem;2024-05-24
2. Exploration of the Tunability of BRD4 Degradation by DCAF16Trans-labelling Covalent Glues;2023-10-10
3. Comparative analysis of biophysical methods for monitoring protein proximity induction in the development of small molecule degraders;Biochimica et Biophysica Acta (BBA) - General Subjects;2023-09
4. From classic medicinal chemistry to state‐of‐the‐art interdisciplinary medicine: Recent advances in proteolysis‐targeting chimeras technology;Interdisciplinary Medicine;2023-04
5. PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components;ACS Chemical Biology;2023-03-06
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3