Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs-Reference-Cited by-同舟云学术

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Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs

Published:2020-07-08 Issue:8 Volume:6 Page:1367-1375
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Bond Michael J.¹,Chu Ling²,Nalawansha Dhanusha A.²,Li Ke²,Crews Craig M.¹²³^ORCID

Affiliation:

1. Department of Pharmacology, Yale University, New Haven, Connecticut 06511, United States

2. Department of Molecular, Cellular, and Developmental Biology, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06511, United States

3. Department of Chemistry, Yale University, New Haven, Connecticut 06511, United States

Funder

U.S. Department of Health and Human Services

American Cancer Society

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acscentsci.0c00411

Reference51 articles.

1. A Comprehensive Survey of Ras Mutations in Cancer

2. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

3. Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

4. Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

5. RAS Proteins and Their Regulators in Human Disease

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2. LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation;2024-09-10

3. PROTAC unleashed: Unveiling the synthetic approaches and potential therapeutic applications;European Journal of Medicinal Chemistry;2024-09

4. Computational Analysis of Treatment Resistant Cancer Cells;2024-08-31

5. Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3^LZTR1 E3 Ligase KRAS Complex;ACS Chemical Biology;2024-08-28

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