Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3<sup>LZTR1</sup> E3 Ligase KRAS Complex-Reference-Cited by-同舟云学术

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Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3^LZTR1 E3 Ligase KRAS Complex

Published:2024-08-28 Issue: Volume: Page:
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Piech Sophie¹,Brüschweiler Sven²,Westphalen Josepha¹,Siess Katharina M.²,García Murias Julio¹,Konrat Robert²³,Bigenzahn Johannes W.¹⁴,Superti-Furga Giulio¹⁵^ORCID

Affiliation:

1. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria

2. MAG-LAB GmbH, 1030 Vienna, Austria

3. Department of Structural and Computational Biology, University of Vienna, 1030 Vienna, Austria

4. Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria

5. Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna Austria

Funder

?sterreichischen Akademie der Wissenschaften

Magistrat der Stadt Wien

Austrian Science Fund

Medizinische Universit?t Wien

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.4c00077

Reference39 articles.

1. RAS isoforms and mutations in cancer at a glance

2. RAS-targeted therapies: is the undruggable drugged?

3. Targeting KRAS Mutant Non-Small-Cell Lung Cancer: Past, Present and Future

4. Overcoming Resistance to Drugs Targeting KRAS Mutation

5. Stopping the beating heart of cancer: KRAS reviewed

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