Amide-functionalized 1,2,4-Triazol-5-amines as Covalent Inhibitors of Blood Coagulation Factor XIIa and Thrombin-Reference-Cited by-同舟云学术

Amide-functionalized 1,2,4-Triazol-5-amines as Covalent Inhibitors of Blood Coagulation Factor XIIa and Thrombin

Published:2022-11-30 Issue:12 Volume:5 Page:1318-1347
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Imberg Lukas¹,Platte Simon¹,Erbacher Catharina²,Daniliuc Constantin G.³^ORCID,Kalinina Svetlana A.⁴^ORCID,Dörner Wolfgang⁵,Poso Antti⁶⁷^ORCID,Karst Uwe²^ORCID,Kalinin Dmitrii V.¹^ORCID

Affiliation:

1. Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster 48149, Germany

2. Institute of Inorganic and Analytical Chemistry, University of Münster, Münster 48149, Germany

3. Institute for Organic Chemistry, University of Münster, Münster 48149, Germany

4. Institute of Food Chemistry, University of Münster, Münster 48149, Germany

5. Institute of Biochemistry, University of Münster, Münster 48149, Germany

6. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio 70211, Finland

7. Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen 72076, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00204

Reference44 articles.

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3. In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate

4. Reversible covalent direct thrombin inhibitors

5. Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors

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