Structure-Based Identification of Kelch-like ECH-Associated Protein 1 as a Pharmacological Target of Electrophile-Containing Catechol-<i>O</i>-Methyltransferase Inhibitors-Reference-Cited by-同舟云学术

Structure-Based Identification of Kelch-like ECH-Associated Protein 1 as a Pharmacological Target of Electrophile-Containing Catechol-O-Methyltransferase Inhibitors

Published:2024-02-13 Issue:3 Volume:7 Page:693-706
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Wang Ping¹²^ORCID,Li Yang²,Yang Jinyi³²,Li Ziwen²,Ren Xintong¹²,Meng Qingshi⁴,Li Pengfei²,Qin Luzhe²⁵,Li Wei⁶,Xie Yuting²,Hou Nannan²,Huang Niu²⁷^ORCID

Affiliation:

1. College of Life Sciences, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing 100875, China

2. National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China

3. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 102206, China

4. State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

5. School of Life Sciences, Tsinghua University, Beijing 100084, China

6. RPXDs (Suzhou) Co., Ltd., Suzhou 215028, China

7. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China

Funder

Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park

Tsinghua University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.3c00281

Reference67 articles.

1. Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone

2. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

3. Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone

4. Mapping the conformational space accessible to catechol-O-methyltransferase

5. Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles