Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1-Reference-Cited by-同舟云学术

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

Published:2019-04-17 Issue:488 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Peng Shiming¹^ORCID,Xiao Wen²^ORCID,Ju Dapeng¹^ORCID,Sun Baofa²³⁴,Hou Nannan¹^ORCID,Liu Qianlan²³,Wang Yanli¹,Zhao Haijiao¹^ORCID,Gao Chunchun²³,Zhang Song⁵,Cao Ran¹,Li Pengfei¹,Huang Huanwei¹,Ma Yongfen¹^ORCID,Wang Yankai¹,Lai Weiyi⁶^ORCID,Ma Zhixiong¹,Zhang Wei¹,Huang Song¹,Wang Hailin⁶,Zhang Zhiyuan¹^ORCID,Zhao Liping¹,Cai Tao¹,Zhao Yong-Liang²³,Wang Fengchao¹,Nie Yongzhan⁵,Zhi Gang¹,Yang Yun-Gui²³⁴,Zhang Eric Erquan¹⁷^ORCID,Huang Niu¹⁷^ORCID

Affiliation:

1. National Institute of Biological Sciences, Beijing, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China.

2. Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, No. 1 Beichen West Road, Chaoyang District, Beijing 100101, China.

3. University of Chinese Academy of Sciences, Beijing 100049, China.

4. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.

5. State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West Changle Road, Xi’an, Shaanxi 710032, China.

6. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

7. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.

Abstract

Entacapone improves metabolic homeostasis in diet-induced obese mice through a direct effect on an FTO-FOXO1 regulatory axis.

Funder

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

National Basic Research Program of China

CAS Strategic Priority Research Program

National Major Scientific and Technological Special Project for “Significant New Drugs Development”

Strategic Priority Research Program A of the Chinese Academy of Sciences

the Chinese "Recruitment Program of Global Youth Experts"

Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund