Orthogonal Deprotection Strategy of Fmoc Provides Improved Synthesis of Sensitive Peptides: Application to Z-Arg-Lys-AOMK-Reference-Cited by-同舟云学术

Orthogonal Deprotection Strategy of Fmoc Provides Improved Synthesis of Sensitive Peptides: Application to Z-Arg-Lys-AOMK

Published:2024-01-05 Issue: Volume: Page:
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Almaliti Jehad¹²^ORCID,Alhindy Momen²,Yoon Michael C.³^ORCID,Hook Vivian³⁴^ORCID,Molinski Tadeusz F.²³⁵^ORCID,O’Donoghue Anthony J.³^ORCID,Gerwick William H.²³

Affiliation:

1. Department Pharmaceutical Sciences, College of Pharmacy, The University of Jordan, Amman 11942, Jordan

2. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States

3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States

4. School of Medicine, Department of Neurosciences, and Department of Pharmacology, University of California San Diego, La Jolla, California 29093, United States

5. Department of Chemistry, University of California San Diego, La Jolla, California 92093, United States

Funder

National Institute of Neurological Disorders and Stroke

St. Baldrick's Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c08629

Reference13 articles.

1. The 9-Fluorenylmethoxycarbonyl (Fmoc) Group in Chemical Peptide Synthesis – Its Past, Present, and Future

2. Advances in Fmoc solid‐phase peptide synthesis

3. Piperazine and DBU: a safer alternative for rapid and efficient Fmoc deprotection in solid phase peptide synthesis

4. A comparison of Boc and Fmoc SPPS strategies for the preparation of C-terminal peptide α-thiolesters: NY-ESO-139Cys-68Ala-COSR

5. Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions

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