Piperazine and DBU: a safer alternative for rapid and efficient Fmoc deprotection in solid phase peptide synthesis-Reference-Cited by-同舟云学术

Piperazine and DBU: a safer alternative for rapid and efficient Fmoc deprotection in solid phase peptide synthesis

Published:2015 Issue:126 Volume:5 Page:104417-104425
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ralhan Krittika¹²³⁴,KrishnaKumar V. Guru¹²³⁴,Gupta Sharad¹²³⁴

Affiliation:

1. Biological Engineering

2. Indian Institute of Technology Gandhinagar

3. Ahmedabad-382424

4. India

Abstract

We demonstrate PolyAla synthesis using 5% piperazine + 2% DBU, which significantly reduces deletion products arising due to incomplete Fmoc-deprotection and can be used for deletion-free assembly of aggregation prone difficult peptides.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA23441G

Reference29 articles.

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4. Peptide synthesis. Part 2. Procedures for solid-phase synthesis using Nα-fluorenylmethoxycarbonylamino-acids on polyamide supports. Synthesis of substance P and of acyl carrier protein 65–74 decapeptide

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