Rational Design, Synthesis, and Mechanism of (3<i>S</i>,4<i>R</i>)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase-Reference-Cited by-同舟云学术

Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase

Published:2022-03-16 Issue:12 Volume:144 Page:5629-5642
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Zhu Wei¹^ORCID,Butrin Arseniy²,Melani Rafael D.³^ORCID,Doubleday Peter F.³^ORCID,Ferreira Glaucio Monteiro⁴^ORCID,Tavares Mauricio T.⁵^ORCID,Habeeb Mohammad Thahani S.¹,Beaupre Brett A.²,Kelleher Neil L.¹³^ORCID,Moran Graham R.²^ORCID,Liu Dali²^ORCID,Silverman Richard B.¹³⁶^ORCID

Affiliation:

1. Department of Chemistry, Chemistry of Life Processes Institute, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States

2. Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States

3. Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States

4. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil

5. Department of Molecular Medicine, Scripps Research, Jupiter, Florida 33458, United States

6. Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States

Funder

Division of Chemistry

National Cancer Institute

Fundação Amazônia Paraense de Amparo à Pesquisa

National Institute on Drug Abuse

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c00924

Reference40 articles.

1. The Properties, Developmental Formation, and Estrogen Induction of Ornithine Aminotransferase in Rat Tissues

2. Chemical, Physical, and Morphological Properties of Ornithine Aminotransferase from Rat Liver

3. The metabolism of proline, a stress substrate, modulates carcinogenic pathways

4. Proline metabolism and cancer

5. The Proline Regulatory Axis and Cancer

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