Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of β-Lactamases-Reference-Cited by-同舟云学术

Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of β-Lactamases

Published:2022-11-03 Issue:45 Volume:144 Page:20947-20954
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Ji Zhe¹^ORCID,Kozuch Jacek²³^ORCID,Mathews Irimpan I.⁴^ORCID,Diercks Christian S.⁵^ORCID,Shamsudin Yasmin⁶^ORCID,Schulz Mirjam A.²³^ORCID,Boxer Steven G.¹^ORCID

Affiliation:

1. Department of Chemistry, Stanford University, Stanford, California 94305, United States

2. Department of Physics, Experimental Molecular Biophysics, Freie Universität Berlin, Arnimallee 14, D-14195 Berlin, Germany

3. Research Building SupraFAB, Altensteinstreet 23a, 14195 Berlin, Germany

4. Stanford Synchrotron Radiation Lightsource, Menlo Park, California 94025, United States

5. Department of Chemistry, Scripps Research, La Jolla, California 92037, United States

6. Department of Chemistry-BMC, Uppsala University, 752 37 Uppsala, Sweden

Funder

Deutsche Forschungsgemeinschaft

Knut och Alice Wallenbergs Stiftelse

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c09876

Reference37 articles.

1. The resurgence of covalent drugs

2. Covalent inhibitors: a rational approach to drug discovery

3. Reimagining Druggability Using Chemoproteomic Platforms

4. Prolonged and tunable residence time using reversible covalent kinase inhibitors

5. Mechanism of Carbamate Inactivation of FAAH: Implications for the Design of Covalent Inhibitors and In Vivo Functional Probes for Enzymes

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