Prolonged and tunable residence time using reversible covalent kinase inhibitors-Reference-Cited by-同舟云学术

Prolonged and tunable residence time using reversible covalent kinase inhibitors

Published:2015-05-25 Issue:7 Volume:11 Page:525-531
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Bradshaw J Michael,McFarland Jesse M^ORCID,Paavilainen Ville O,Bisconte Angelina,Tam Danny,Phan Vernon T,Romanov Sergei,Finkle David,Shu Jin,Patel Vaishali,Ton Tony,Li Xiaoyan,Loughhead David G,Nunn Philip A,Karr Dane E,Gerritsen Mary E,Funk Jens Oliver,Owens Timothy D,Verner Erik,Brameld Ken A,Hill Ronald J,Goldstein David M,Taunton Jack

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.1817.pdf

Reference51 articles.

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3. Lu, H. & Tonge, P.J. Drug-target residence time: critical information for lead optimization. Curr. Opin. Chem. Biol. 14, 467–474 (2010).

4. Guo, D., Hillger, J.M., IJzerman, A.P. & Heitman, L.H. Drug-target residence time—a case for G protein-coupled receptors. Med. Res. Rev. 34, 856–892 (2014).

5. Swinney, D.C. et al. A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands. Br. J. Pharmacol. 171, 3364–3375 (2014).

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