Sequence-Specific Formation of d-Amino Acids in a Monoclonal Antibody during Light Exposure
Author:
Affiliation:
1. Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/mp500508w
Reference38 articles.
1. Protect from Light: Photodegradation and Protein Biologics
2. Forced Degradation of Therapeutic Proteins
3. Exposure of a Monoclonal Antibody, IgG1, to UV-Light Leads to Protein Dithiohemiacetal and Thioether Cross-Links: A Role for Thiyl Radicals?
4. Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form
5. The oxidative environment and protein damage
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