Exposure of a Monoclonal Antibody, IgG1, to UV-Light Leads to Protein Dithiohemiacetal and Thioether Cross-Links: A Role for Thiyl Radicals?-Reference-Cited by-同舟云学术

Exposure of a Monoclonal Antibody, IgG1, to UV-Light Leads to Protein Dithiohemiacetal and Thioether Cross-Links: A Role for Thiyl Radicals?

Published:2010-07-06 Issue:8 Volume:23 Page:1310-1312
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Mozziconacci Olivier¹,Kerwin Bruce A.¹,Schöneich Christian¹

Affiliation:

1. Department of Pharmaceutical Chemistry, 2095 Constant Avenue, University of Kansas, Lawrence, Kansas 66047, and Department of Analytical and Formulation Science, Process and Product Development, Amgen Inc., 1201 Amgen Court West, Seattle, Washington 98119

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx100193b

Reference18 articles.

1. Guidelines to cell engineering for monoclonal antibody production

2. Industrialization of mAb production technology: The bioprocessing industry at a crossroads

3. Recent advances in large-scale production of monoclonal antibodies and related proteins

4. Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form

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