Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization
Author:
Affiliation:
1. Chemical Biology Platform, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, United States
Publisher
American Chemical Society (ACS)
Subject
General Chemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/co200161z
Reference26 articles.
1. An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors
2. Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles
3. Accessing Skeletal Diversity Using Catalyst Control: Formation of n and n + 1 Macrocyclic Triazole Rings
4. Synthesis of a Stereochemically Diverse Library of Medium-Sized Lactams and Sultams via SNAr Cycloetherification
5. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
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