Total Syntheses and Anticholinesterase Activities of (3aS)-N(8)-Norphysostigmine, (3aS)-N(8)-Norphenserine, Their Antipodal Isomers, and Other N(8)-Substituted Analogues-Reference-Cited by-同舟云学术

Total Syntheses and Anticholinesterase Activities of (3aS)-N(8)-Norphysostigmine, (3aS)-N(8)-Norphenserine, Their Antipodal Isomers, and Other N(8)-Substituted Analogues

Published:1997-08-01 Issue:18 Volume:40 Page:2895-2901
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yu Qian-sheng¹,Pei Xue-Feng¹,Holloway Harold W.¹,Greig Nigel H.¹,Brossi Arnold²

Affiliation:

1. Drug Design & Development, Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 4940 Eastern Avenue, Baltimore, Maryland 21224

2. School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7360

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970210v

Reference26 articles.

1. Clinical pharmacokinetics of physostigmine in patients with Alzheimer's disease*

2. Phenserine and ring C hetero-analogues: Drug candidates for the treatment of Alzheimer's disease

3. Phenserine, a Novel Anticholinesterase Related to Physostigmine: Total Synthesis and Biological Properties

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