In Silico and Ex Vivo Analyses of the Inhibitory Action of the Alzheimer Drug Posiphen and Primary Metabolites with Human Acetyl- and Butyrylcholinesterase Enzymes

Author:

Batool Sidra1,Furqan Tiyyaba2,Hasan Mahmood Muhammad Sibte3,Tweedie David4,Kamal Mohammad A.5678,Greig Nigel H.4ORCID

Affiliation:

1. Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia

2. Department of Biosciences, COMSATS University, Park Road, Chak Shahzad, Islamabad 45550, Pakistan

3. Medicine Department, Grand River Hospital, 835 King Street W, Kitchener, Ontario N2G 1G3, Canada

4. Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, United States

5. West China School of Nursing / Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041 Sichuan, China

6. King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia

7. Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Khagan, Dhaka 1340, Bangladesh

8. Enzymoics, Novel Global Community Educational Foundation, Hebersham, NSW 2770, Australia

Funder

National Institute on Aging

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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