Carltonine-derived compounds for targeted butyrylcholinesterase inhibition-Reference-Cited by-同舟云学术

Carltonine-derived compounds for targeted butyrylcholinesterase inhibition

Published:2024 Issue:5 Volume:15 Page:1601-1625
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Pidany Filip¹,Kroustkova Jana¹,Jenco Jaroslav¹^ORCID,Breiterova Katerina Hradiska¹,Muckova Lubica²³,Novakova Lucie⁴^ORCID,Kunes Jiri⁵,Fibigar Jakub³,Kucera Tomas³,Novak Martin²,Sorf Ales³,Hrabinova Martina²³,Pulkrabkova Lenka²³,Janousek Jiri²,Soukup Ondrej²³,Jun Daniel³^ORCID,Korabecny Jan²³^ORCID,Cahlikova Lucie¹^ORCID

Affiliation:

1. Faculty of Pharmacy in Hradec Kralove, Department of Pharmacognosy and Pharmaceutical Botany, Charles University, Akademika Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic

2. Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic

3. Military Faculty of Medicine, Department of Toxicology and Military Pharmacy, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic

4. Faculty of Pharmacy in Hradec Kralove, Department of Analytical Chemistry, Charles University, Akademika Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic

5. Faculty of Pharmacy in Hradec Kralove, Department of Bioorganic and Organic Chemistry, Charles University, Akademika Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic

Abstract

Innovative chemotype design provided 41 novel hBChE inhibitors. CNS availability was predicted using the BBB score. Potent derivatives showed favorable drug-like properties and acceptable safety profiles in SH-SY5Y and HepG2 cells.

Funder

Univerzita Karlova v Praze

Fakultní nemocnice Hradec Králové

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00060A

Reference89 articles.

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4. Processing of Cholinesterase-like α/β-Hydrolase Fold Proteins: Alterations Associated with Congenital Disorders

5. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease

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