Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure-Reference-Cited by-同舟云学术

Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure

Published:2013-08-27 Issue:17 Volume:56 Page:7110-7119
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Griffith David A.¹,Dow Robert L.¹,Huard Kim¹,Edmonds David J.¹,Bagley Scott W.¹,Polivkova Jana¹,Zeng Dongxiang¹,Garcia-Irizarry Carmen N.¹,Southers James A.¹,Esler William¹,Amor Paul¹,Loomis Kathrine¹,McPherson Kirk¹,Bahnck Kevin B.¹,Préville Cathy¹,Banks Tereece¹,Moore Dianna E.¹,Mathiowetz Alan M.¹,Menhaji-Klotz Elnaz¹,Smith Aaron C.¹,Doran Shawn D.¹,Beebe David A.¹,Dunn Matthew F.¹

Affiliation:

1. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401033t

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4. Continuous fat oxidation in acetyl CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

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