Synthesis, Cytotoxicity, DNA Interaction, and Topoisomerase II Inhibition Properties of Novel Indeno[2,1-c]quinolin-7-one and Indeno[1,2-c]isoquinolin-5,11-dione Derivatives-Reference-Cited by-同舟云学术

Synthesis, Cytotoxicity, DNA Interaction, and Topoisomerase II Inhibition Properties of Novel Indeno[2,1-c]quinolin-7-one and Indeno[1,2-c]isoquinolin-5,11-dione Derivatives

Published:2008-05-29 Issue:12 Volume:51 Page:3617-3629
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ryckebusch Adina¹,Garcin Deborah¹,Lansiaux Amélie¹,Goossens Jean-François¹,Baldeyrou Brigitte¹,Houssin Raymond¹,Bailly Christian¹,Hénichart Jean-Pierre¹

Affiliation:

1. UMR 8009 “Chimie Organique et Macromoléculaire”, Laboratoire de Chimie Organique Physique, Bâtiment C3(2), Université des Sciences et Technologies de Lille, 59655 Villeneuve d’Ascq, France, Institut de Chimie Pharmaceutique Albert Lespagnol, EA 2692, Université de Lille 2, BP 83, 59006 Lille, France, INSERM U-837 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret (COL), IRCL, Place de Verdun, 59045 Lille, France, and Laboratoire de Chimie Analytique, EA 4034, Faculté des Sciences...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800017u

Reference37 articles.

1. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2,1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells

2. Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

3. Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity

4. Phase I Clinical and Pharmacogenetic Study of Weekly TAS-103 in Patients With Advanced Cancer

5. Topoisomerase I inhibitors: camptothecins and beyond

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