Affiliation:
1. Chemistry Faculty of Science, Mansoura University Mansoura 35516 Egypt
2. Chemistry of Natural Compounds National Research Centre Dokki, Giza 12622 Egypt
3. Polymers and Pigments National Research Centre Dokki, Giza 12622 Egypt
4. Chemistry Faculty of Science, Menoufia University Shebin El-Koam 32511 Egypt
5. Photochemistry National Research Centre Dokki, Giza 12622 Egypt
6. Basic Science High Institute of Engineering & Technology ElMahalla Elkobra 3511 Egypt
Abstract
AbstractA series of some new 1,3,4‐oxadiazole derivatives was synthesized. Hydrazide derivative 4 was reacted with some sugar aldehydes to give the corresponding sugar hydrazones 5 a–c. Acetylation of 5 a–c with acetic anhydride in pyridine, managed the per‐O‐acetyl derivatives 6 a–c while refluxing in acetic anhydride gave the corresponding 1,3,4‐oxadiazolines 7 a–c. On the other hand, 1,3,4‐oxadiazoles 8 a,b, 9, 10, 12, 14, and 15 were synthesized via the reaction of 4 with different reagents including p‐chlorobenzoic acid, nicotinic acid, methyl iodide, morpholine, phenyl isothiocyanate, potassium iodide, chloroacetyl chloride, and phosphorus oxychloride, respectively. The new compounds were assessed for their anticancer and antioxidant activities. Compounds 8 a,b, 10, and 12–15 displayed the most antioxidant activity. In addition, compounds 8 a, 8 b, and 13 showed strong cytotoxic activity.