An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2,1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells-Reference-Cited by-同舟云学术

An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2,1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells

Published:2000-09 Issue:6 Volume:60 Page:817-821
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Padget Kay,Stewart Alistair,Charlton Peter,Tilby Michael J,Austin Caroline A

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference19 articles.

1. DNA topoisomerases;Wang;Annu Rev Biochem,1996

2. From amsacrine to DACA (N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide);Finlay;Eur J Cancer,1996

3. Antitumour activity of a novel quinoline derivative, TAS-103, with inhibitory effects on topoisomerase I and II;Utsugi;Jpn J Cancer Res,1997

4. Intoplicine (RP-60475) and its derivatives, a new class of antitumour agents inhibiting both topoisomerase I and II activities;Riou;Cancer Res,1993

5. Dual topoiosmerase I and II inhibition by intoplicine (RP-60475), a new antitumour agent in early clinical trials;Poddevin;Mol Pharmacol,1993

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