Synthesis of Pyridopyrazine-1,6-dione γ-Secretase Modulators via Selective 4-Methylimidazole N1-Buchwald Arylation-Reference-Cited by-同舟云学术

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Synthesis of Pyridopyrazine-1,6-dione γ-Secretase Modulators via Selective 4-Methylimidazole N1-Buchwald Arylation

Published:2019-01-08 Issue:8 Volume:84 Page:4921-4925
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Xie Longfei¹,am Ende Christopher W.¹^ORCID,Pettersson Martin²,Rankic Danica A.¹^ORCID,Sach Neal W.³,Sakya Subbas¹,Humphrey John M.¹^ORCID

Affiliation:

1. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

2. Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States

3. Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.8b02953

Reference19 articles.

1. 2008 Alzheimer's disease facts and figures

2. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

3. A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

4. The Many Substrates of Presenilin/γ-Secretase

5. Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012

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1. Novel Ferrocenyl‐azole Derivatives: Synthesis, DFT Calculation and Unlocking the Anticancer Potential;European Journal of Organic Chemistry;2024-05-23

2. Imidazoles;Comprehensive Heterocyclic Chemistry IV;2022

3. Condensed Pyridopyrimidines and Pyridopyrazines Containing a Bridgehead Nitrogen Atom: Synthesis, Chemical Properties and Biological Activity;Current Organic Chemistry;2021-07-14

4. Recent developments in selective N-arylation of azoles;Chemical Communications;2021

5. NGP 555, a γ‐secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses;Alzheimer's & Dementia: Translational Research & Clinical Interventions;2019-01

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