Diastereoselective Synthesis of Enantioenriched Trifluoromethylated Ethylenediamines and Isoindolines Containing Two Stereogenic Carbon Centers by Nucleophilic Trifluoromethylation Using HFC-23-Reference-Cited by-同舟云学术

Diastereoselective Synthesis of Enantioenriched Trifluoromethylated Ethylenediamines and Isoindolines Containing Two Stereogenic Carbon Centers by Nucleophilic Trifluoromethylation Using HFC-23

Published:2020-05-18 Issue:12 Volume:85 Page:7976-7985
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Hirano Kazuki¹,Saito Takuya¹,Fujihira Yamato¹,Sedgwick Daniel M.²,Fustero Santos²^ORCID,Shibata Norio¹³^ORCID

Affiliation:

1. Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-5888, Japan

2. Departmento de Química Orgánica, Universitat de València, Burjassot 46100, Spain

3. Institute of Advanced Fluorine-Containing Materials, Zhejiang Normal University, 688 Yingbin Avenue, Jinhua 321004, China

Funder

Asahi Glass Foundation

Japan Society for the Promotion of Science

Tosoh Finechem Corporation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.0c00796

Reference46 articles.

1. Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

2. Fluorine in medicinal chemistry

3. Contribution of Organofluorine Compounds to Pharmaceuticals

4. Applications of Fluorine in Medicinal Chemistry

5. Progress in copper-catalyzed trifluoromethylation

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