Affiliation:
1. Manganese Catalysis and Asymmetric Synthesis Laboratory, College of Chemistry and Pharmaceutical Engineering, Hebei University
of Science and Technology, Shijiazhuang 050018, People’s Republic of China
Abstract
:
Due to the robust electrophilic properties of the trifluoromethyl group (-CF3), its
incorporation into organic compounds can markedly alter their ester affinity, stability, bioavailability,
and other properties. The trifluoromethylation reaction is currently experiencing
rapid advancement, with an expanding array of substrates and the emergence of novel
methodologies. Consequently, compounds containing the -CF3 moiety find extensive utility
across diverse fields. This article aims to comprehensively review the latest advancements
in trifluoromethylation reaction of olefins, aldehydes, and ketones, encompassing
nucleophilic trifluoromethylation, electrophilic trifluoromethylation, and radical trifluoromethylation.
The discussion includes an exploration of the types and broadening scope of
applicable substrates. Furthermore, this article addresses the associated challenges and delineates
prospective directions for future developments in trifluoromethyl reaction.
Publisher
Bentham Science Publishers Ltd.