The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems-Reference-Cited by-同舟云学术

The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems

Published:2016-04-25 Issue:9 Volume:81 Page:3509-3519
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Smith Aaron C.¹,Cabral Shawn¹,Kung Daniel W.¹,Rose Colin R.¹,Southers James A.¹,García-Irizarry Carmen N.¹,Damon David B.¹,Bagley Scott W.¹,Griffith David A.¹

Affiliation:

1. Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, United States

Funder

Pfizer

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5b02890

Reference28 articles.

1. Two‐ and Three‐dimensional Rings in Drugs

2. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

3. Escape from Flatland 2: complexity and promiscuity

4. Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

5. Lipophilicity in drug discovery

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